Endocrine Abstracts

Introduction: SOCS2 is an important negative regulator of post-natal growth, as demonstrated by the SOCS2 null overgrowth phenotype. We have used SOCS2−/− mice, alongside chondrocytes overexpressing SOCS2, to investigate the mode of action of SOCS2 at the epiphysis. SOCS2 maybe involved in growth retardation associated with chronic inflammatory disorders, therefore we studied LPS induced growth retardation in wild type (WT) and SOCS2−/−<...

Introduction: GH signalling is essential for post-natal linear bone growth. The systemic/local mechanisms responsible for GH action remain unclear as the importance of liver derived IGF1 on linear growth has recently been challenged.Aim: To unravel the underlying mechanisms of linear bone growth we exploited the suppressor of cytokine signalling-2 (SOCS2) KO mice which have enhanced linear growth despite normal systemic IGF1 and GH levels.<p class="a...